Treatment is geared toward relieving the intense itching and rash that accompany this disorder. The underlying cause of Grover's disease isn't clear, though it may be related to sweat gland obstruction occlusion with sweat dispersion in the upper layers of the skin. The disorder is most common in older white men. A history of significant sun exposure, heat, sweating and, occasionally, dry skin increase the risk of Grover's disease.
Some people develop this condition in the hospital while lying on their backs for an extended time. In patients who develop Grover's disease in the hospital, symptoms may disappear when the patient becomes mobile again. For people who have more persistent cases associated with sun-damaged or dry skin, symptoms of Grover's disease tend to come and go.
In these individuals, the disease may flare when they are exposed to exacerbating factors such as high temperatures, sweating, or very dry skin.
To decrease the effects of Grover's disease, the first line of treatment is to avoid factors that can cause and aggravate the condition, such as high environmental temperatures, significant sweating, and dry skin. See more images of transient acantholytic dermatosis. Transient acantholytic dermatosis may be complicated by the development of dermatitis , usually in a discoid pattern with round or oval, dry or crusted plaques.
The plaques start on the chest and back and may spread to affect the limbs. Transient acantholytic dermatosis is usually diagnosed clinically, but a skin biopsy may be necessary. The pathology of transient acantholytic dermatosis is characteristic, with acantholysis separated skin cells with or without dyskeratosis abnormal rounded skin cells. Spongiotic dermatitis may also be noted.
Four histological patterns are recognised, not all of which show the classic acantholytic pattern. There is no curative treatment for transient acantholytic dermatosis, but the following suggestions may relieve the itch and hasten resolution. If using a BRAF- inhibitor , the addition of a MEK -inhibitor seems to protect against the development of transient acantholytic dermatosis.
The duration of transient acantholytic dermatosis is variable although spontaneous self-resolution in weeks is typical. It can come and go, often with a seasonal variation. Although it is called transient, Grover disease is often relapsing and can be chronic persisting for years.
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